Injectable Methacrylated Alginate Cryogels for the Minimally Invasive Treatment of Bone Nonunion

Injectable Methacrylated Alginate Cryogels for the Minimally Invasive Treatment of Bone Nonunion

Student(s):

Tracy Lu

Advisor(s):

Gary Bledsoe, Ph.D., Chair and Professor of Biomedical Engineering

Cryogels are a unique scaffold formed at subzero temperatures, creating a spongey, macroporous structure. Recent studies have demonstrated the scaffold’s shape memory properties and resistance to shear forces when pushed through a standard needle-syringe. This project aims to utilize these fabrication methods to create an injectable, osteoconductive scaffold for the treatment of nonunion bone. Ongoing characterization is being conducted to determine the ideal pore size and mechanical properties. Future research will explore the addition of various dopants for increased mineralization of the scaffold. Such properties would identify methacrylated alginate cryogels as an ideal scaffold in bone regeneration.