The Effects of Lesioning the Globus Pallidus on Recovery Sleep

The Effects of Lesioning the Globus Pallidus on Recovery Sleep


Natalie Fording


Dr. Barnett & Dr. A. Michael Anch

Millions of Americans are affected by sleep disorders every year. Two fundamental processes, circadian rhythm and homeostasis, are in control of sleep regulation. While much is known about the location and function of the circadian rhythm, there has been very little research on the location of homeostatic sleep regulation. The goal of this study was to observe the effects of lesioning the globus pallidus on recovery sleep. To do this, two groups of male rats between 280-320g were used. The experimental group experienced a unilateral lesion to the left side of the globus pallidus with ibotenic acid and the control group experienced a ‘sham’ lesion with saline. Electrodes were implanted to record ECoG, EMG, and Theta wave activity to score wake, high voltage, and paradoxical sleep stages. Results showed that the experimental group had an increase in wake and a decrease in high voltage and paradoxical sleep when compared to control rats. Further research would include a larger number of subjects for a continuation of this study. Also, studies that include methodologies from previous research on sleep deprivation on rat models, such as increase in sleep deprivation time period, would help verify the role of the globus pallidus in homeostatic sleep regulation.