NIH Grant Awarded to Jessica Wagenseil, D.Sc.
July 23, 2012
Biomedical Engineering, Parks College News, Research
Jessica Wagenseil, D.Sc., Assistant Professor of Biomedical Engineering at Saint Louis University’s Parks College of Engineering, Aviation and Technology was awarded a grant from The National Institutes of Health (NIH) in the amount of $375,000. The grant will support Dr. Wagenseil’s Biomechanical Factors in Congenital Vascular Disease project.
Goals of Dr. Wagenseil’s NIH Grant Project
The most common congenital vascular defect is coarctation of the aorta, which has a mortality rate of 75 percent by 45 years of age if untreated. Treatment is usually recommended before five years of age and treatment complications include operative mortality, recoarctation and aneurysms.
The goal of the proposed research is to test the hypothesis that coarctation is caused by changes in the vascular cell phenotype when there are alterations in the mechanical environment and that coarctation can be prevented by reversing the changes in the mechanical environment.